Determinants of survival in children with cancer in Johannesburg, South Africa

Determinants of survival in children with cancer in Johannesburg, South Africa

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Background: Childhood cancer, although rare, remains an important cause of death worldwide.The outcomes of children with all cancer types in South Africa are not well-documented.Aim: The aim of the article was to determine local childhood cancer survival rates and establish determinants of survival.Setting: The study was conducted at a redken shades eq dark chocolate state and a private hospital in South Africa.Methods: This retrospective cohort study consecutively included all children with a proven malignancy from 01 January 2012 to 31 December 2016.

Univariable and multivariable analyses were used to establish which factors significantly impacted overall survival (OS).Results: Of a total of 677 study participants, 71% were black South Africans.The estimated 5-year overall survival (OS) was 57% (95% confidence interval [CI]: 53-61%) and significant determinants of OS on the multivariable analysis included: ethnicity, cancer-type and nutritional status.White and Indian patients had higher OS compared to black patients (hazard ration [HR] (95% CI) 0.46 (0.

30-0.69) p = 0.0002 and HR (95%) 0.38 (0.19-0.

78) p = 0.0087, respectively).Underweight patients had inferior survival (HR (95% CI) 1.78 (1.28-2.

47)) p = 0.0006.Patients with neuroblastoma had an increased risk of dying compared to those with leukaemia (HR [95% CI] 1.78 [1.08-2.

94]) p = 0.025.Progression of disease was the most common cause of death, followed by disease relapse.Conclusion: air compressor tank bushing The childhood cancer survival rate obtained in this study can be used as a baseline to facilitate improvement.Non-modifiable prognostic factors included ethnicity and cancer-type whilst modifiable risk factors included undernutrition.

Undernutrition should be addressed on a national and local level to improve survival.